Research Associate

  • location: Cambridge, MA
  • type: Contract
  • salary: $38.25 - $45 per hour
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job description

Research Associate

Job Title: Sr. Research Associate, In Vivo Pharmacology

Job Summary

  • The Oncology team is looking for a talented and motivated in vivo pharmacologist to focus on validating new mRNA based therapies in cancer.
  • The successful candidate will primarily work with in vivo tumor models and be responsible for validating the in vivo pharmacology and therapeutic utility of novel mRNA therapeutics.
  • Applicants should be great team members and have a track record of independent research accomplishments.
  • The ability to effectively communicate with internal team members is required.
Job Responsibilities

  • Perform and/or take lead on routine in vivo pharmacology studies (including tumor growth kinetics, tolerability, anti-tumor efficacy, formulations screens, in vivoexpression, biodistribution, and pharmacokinetic and pharmacodynamic studies)
  • Organize and perform all tasks associated with routine in vivo pharmacology studies (including tissue culture, preparation and identification, implantation of cancer cells/materials, preparation of test articles, dose administration and necropsy and tissue collection for downstream processing).
  • Develop new mouse models of cancer to test various messenger RNA therapeutics

    ·
  • Study data collection with StudyLog and analysis with GraphPad Prism software
  • Matrix with internal teams on initial testing of mRNAs
  • Adhere to all protocols, policies and guidelines
  • Deliver reproducible results under aggressive timelines
  • Independently organize experiments
  • Analyze, interpret and present data
  • Faithfully document scientific work; contribute to reports and presentations
Education & Qualifications

  • B.S. in a biological science with >2 years relevant full-time hands on in vivo experience; M.S. with >1 year relevant full-time hands on in vivo experience
  • Solid background in tumor biology and pharmacology
  • Expertise in the following:

    o Pharmacological agent administration via iTu, IV, IP, SC, IM and PO dosing routes

    o Implantation of cancer cell lines and tumor-derived material in SC space

    o Collection of serum/plasma/whole blood, tissues, primary tumor material and metastases

    o Mouse anesthesia/analgesia

    o Animal surgeries

    o Whole animal and ex vivo imaging
  • Tissue/cell culture expertise
  • Cell passaging, archiving for implant
  • Effective oral and written communication skills
  • Readily adapt to change and new projects
  • Expertise in the following:

    o Development of advanced local, systemic, disseminated, or orthotopic syngeneic tumor models

    o Expertise in performing anti-tumor efficacy and PK/PD studies across multiple syngeneic tumor models

    o Experience working with patient-derived xenografts

    o Bioluminescent/fluorescence imaging using an IVIS Spectrum In Vivo Imaging System and Living Image software

    o Advanced necropsy and tissue collection
  • Must be able to work weekends on a rotating schedule
Benefits

  • Medical, Dental, and Vision Insurance
  • 401K Plan with Company Match
  • Life and AD&D Insurance
Equal Opportunity Employer: Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status.

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