- Our research team in Cambridge, MA is seeking a self-motivated, energetic and creative biologist to take part in the development of novel therapeutics for the treatment autoimmune and inflammatory diseases with high unmet medical need.
- This individual will have the opportunity to make significant and high-impact contributions in a small dynamic group setting on multiple drug discovery programs in the areas of T-cell function, immunometabolism, and the gut microbiome.
location: Cambridge, Massachusetts
job type: Contract
salary: $34.19 - 40.22 per hour
work hours: 9 to 5
- Perform hands-on experimentation using a wide range of molecular and cellular techniques suitable for drug target identification and validation, including development of rodent and human cell- and tissue-based immunoassays.
- Work in partnership with cross-functional project teams to investigate the biology of novel targets and to evaluate the effects of newly developed drug lead candidates on immune cell function.
- Generate, analyze, interpret, and present experimental results in a small group setting.
- Generate study reports and maintain a detailed record of experiments in electronic lab notebooks in accordance with company policy.
- Share in responsibilities to support general lab functions.
- Ph.D. in Immunology/Cell Biology/Pharmacology or related discipline with relevant immunology research experience plus 2 years' post-doctoral experience in an academic, institutional, or industrial setting
- Excellent written and oral communication skills
- Ability to work effectively in a multidisciplinary matrix environment
- Team spirit and excellent interpersonal skills
- Learning agility and a strong desire to continuously improve and develop
- Self-motivated and meticulous, with focus on critical and innovative thinking
- Demonstrated track record of productivity in the immunology field, as evidenced by peer-reviewed publications in high impact peer-reviewed journals and/or patents.
- Proficiency across a range of immunological techniques, including but not limited to the following (in order of priority):
- Multi-color flow cytometry (FACS panel design; data acquisition, analysis, and reporting)
- Isolation of immunocyte subsets and cell-based assay development using primary rodent and human immune cells and immortalized cell lines
- Multi-plex protein detection (ELISA, Luminex, MSD)
- Gene expression analysis (TaqMan, NanoString, NGS)
- Molecular biology (transfection, stable cell line generation, Western Blot)
Strong preference will be given to candidates with hands-on experience utilizing functional genomics approaches (si/hRNA, CRISPR-Cas) for phenotypic screening and target ID/validation in cell lines or primary immune cells.
If you have the following characteristics, it would be a plus:
- Previous drug discovery experience in a biopharmaceutical setting
- Experience with pre-clinical models of autoimmunity autoimmune models (SLE, EAE, RA, IBD) and their application towards genetic and pharmacological target validation and drug development
- Familiarity with the pathogenic mechanisms underlying human autoimmune and inflammatory diseases such as rheumatoid arthritis, osteoarthritis, lupus, and inflammatory bowel disease
skills: Molecular Biology, Cell Biology
Equal Opportunity Employer: Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status.