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location: Cambridge, Massachusetts
job type: Contract
salary: $44.75 - 52.65 per hour
work hours: 9 to 5
Alzheimer's Disease and Dementia Research Unit (AD&D RU) at the company seeks an accomplished and driven scientist to join their team in a contract position. The AD&D RU is focused on leveraging genetics and human biology for developing and delivering innovative therapeutic intervention strategies for AD and other dementias.
The candidate will be a part of a fast-faced and motivated drug discovery group and will be directly contributing to drug discovery for AD.
The Alzheimer's Disease & Dementia Research Unit at the company is seeking a highly talented and motivated scientist to join a fast-paced and driven drug discovery group that is focused on the identification and rapid progression of novel therapeutics for Alzheimer's disease in the role of a Contract Position. The candidate will be responsible for:
- Developing and executing new assays with focus on lipid biology and neurovascular biology in Alzheimer's disease.
- Independently designing and executing in vitro and in vivo biology experiments, including mechanism of action studies for drug discovery programs.
- Demonstrating scientific and technical leadership; and, be able to lead from the bench, generate high quality data, perform data analysis and interpretation, and present at team meetings while following high scientific rigor.
- Working effectively and collaboratively with members of the group.
- Ph.D. in neuroscience or biological sciences with a minimum of 4 years of post-doctoral training and 2 years of drug discovery experience in industry in neuroscience.
- An in-depth, up-to-date knowledge of concepts and hands-on experience in cellular and molecular neuroscience and application in AD or other neurodegenerative diseases.
- In-depth experience with cell culture including cell lines, primary tissue culture, and iPSC-derived culture with a strong focus on astrocytes and microglial systems.
- In-depth expertise in biochemical techniques and technologies including immunoblotting, ELISA, MSD, FRET, luminescence, co-immunoprecipitation.
- In-depth expertise in molecular biology techniques such as nucleic acid purification from mammalian cells and tissue (both gDNA and RNA), reverse transcription and qPCR.
- Prior experience with in vivo pharmacology (must be willing to work with animals).
- Experience with general microscopy, immunofluorescent staining, and high content imaging is a plus.
- Experience with apoE, lipid biology and neurovascular biology is a plus.
- Keen understanding of experimental design, underlying scientific principles, and the ability to rigorously analyze and document results.
- Strong interpersonal and organizational skills, ability to work effectively in a collaborative environment, ability to clearly communicate results to a scientific audience and to maintain detailed written records.
- Experience of independent research in a pharmaceutical/biotechnology industry or related setting.
- Drug discovery experience in neuroscience.
skills: Biology, In Vitro, In Vivo
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