We are seeking to fill a contractor position reporting to the Global Chemistry organization in Cambridge, MA to prepare formulated API for in vivo PK, pharmacology, and safety studies. This role entails collaboration with a wide range of cross-functional research project teams, external CRO collaborators, and company Pharm Sci colleagues to develop project specific formulation strategies for in vivo studies (PK, efficacy, tox), enabling the rapid advancement of compounds from PE through CN and CS.
location: Cambridge, Massachusetts
job type: Contract
salary: $40 - 45 per hour
work hours: 9 to 5
education: Bachelors
responsibilities:
- Prepares and optimizes pre-clinical drug formulations using appropriate technology and scientific principles for in vivo PK, Pharmacology, and safety studies
- Conducts limited screening of known excipients, pH adjustment, etc, and chemical/physical stability check for program compounds. Prepares cassette dosing solutions for PK screening.
- Conducts experiments and analyzes/shares data to support project progression using analytical instrumentation (HPLC, Mass Spec) to assess formulation stability and chemical stability
- Accurately records formulation experiments/protocols in an e-notebook
- Prepares/shares formulation protocols, technical reports, presentations, and regulatory documents as necessary
- Adherence to lab safety and quality protocols
- Ensures formulations meet IUCUC guidelines and industry standards in coordination with in vivo study director
- Understanding and ability to implement good laboratory practices, particularly in handling preclinical pharmaceutical small molecule API for neuroscience, immunology, and oncology indications
- Collaborates with a Global Chemistry manager, cross-functional research project teams, CROs, the Comparative Medicine group, and Pharmaceutical Science colleagues to provide project specific formulations and formulations strategies for in vivo studies (PK, efficacy, tox)
- Continuous review and learning of formulation science through reading the literature and active engagement with company Pharm Sci group and CROs to guide project formulation strategy
- Exceptional organizational skills will be required, as the role requires receiving, managing, and delivering on requests from a wide range of groups and teams across the Research organization, often under tight timelines
qualifications:
Required:
- Bachelors degree in a chemistry or pharmaceutical science, or equivalent with 5+ years of experience, OR Master's degree with 3+ years of experience in formulating small molecule APIs
- Broad knowledge of acceptable excipients and equipment/instruments widely used in pre-clinical formulation preparation
- Demonstrates technical knowledge of formulations and pharmaceutics of small molecule APIs including:
- Solubilizing/solution formulations
- Solid/suspension formulations
- Well-versed in analytical instrumentation (HPLC, Mass Spec) to assess:
- Formulation stability (physical)
- Chemical stability
- A good understanding of pre-clinical formulation science
- Exposure to hazardous/toxic/dangerous chemicals
skills: In Vivo, Small Molecules, High Pressure Liquid Chromatography (HPLC), Mass Spectrometry (MS), Active Pharmaceutical Ingredient (API)
Equal Opportunity Employer: Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status.
At Randstad, we welcome people of all abilities and want to ensure that our hiring and interview process meets the needs of all applicants. If you require a reasonable accommodation to make your application or interview experience a great one, please contact HRsupport@randstadusa.com.
Pay offered to a successful candidate will be based on several factors including the candidate's education, work experience, work location, specific job duties, certifications, etc. In addition, Randstad offers a comprehensive benefits package, including: medical, prescription, dental, vision, AD&D, and life insurance offerings, short-term disability, and a 401K plan (all benefits are based on eligibility).
This posting is open for thirty (30) days.
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
