Our client is looking for bioanalytical scientists to join a protein mass spectrometry laboratory in the Pharmacokinetics Dynamics and Metabolism department or a multidisciplinary Manufacturing Sciences and Technology (MSAT) Upstream Group. Roles involve small scale preparation of biological samples for mass spectrometry measurement, or supporting late-stage development of commercial biopharmaceuticals and vaccines focusing on fermentation processes. Responsibilities include process troubleshooting, process improvements, and second-generation process development. The successful candidate will be detail-oriented, able to operate independently, and passionate about learning and applying new skills.
location: Andover, Massachusetts
job type: Contract
salary: $40 - 42 per hour
work hours: 9 to 5
education: Bachelors
responsibilities:
- Preparation of biological samples for mass spectrometry analysis (e.g., lysis, protein immunoprecipitation, protein digestions, filtration, pre-concentrations of proteins and peptide digests).
- Design of experiments in collaboration with colleagues.
- Conduct analytical experiments and method development as needed.
- Identify and exploit new scientific concepts.
- Interpretation and documentation of experimental results.
- Communication of experimental results to team members and management.
- Maintaining high quality records in electronic lab notebooks.
- Operation and user-level maintenance of laboratory equipment (LC-MS, benchtop bioreactors) and associated documentation.
- Planning and executing upstream process experiments at benchtop scales.
- Acting as a technical resource and mentoring junior colleagues.
- Working under limited supervision and managing own time to meet targets.
- Contributing to a safe, efficient, and harmonious lab environment.
- Participating in multi-disciplinary teams to resolve complex issues.
- Assisting in manufacturing investigations, process troubleshooting, and process improvement projects.
- Developing "fit-for-purpose" assays and bioanalytical workflows.
- Working with different types of samples (biological fluids, tissues) from pre-clinical species.
qualifications:
Education & Qualifications:
- Research Associate: BS/MS degree in chemistry, biological sciences, biochemistry, or related fields (NON-PhD). BS with 3+ years experience OR MS with 1+ year experience.
- Senior Associate Scientist: Ph.D. with 0-4 years of experience in biotechnology OR Master's degree in a relevant discipline with 3-5 years of applicable bioprocess experience OR Bachelor's degree with at least 7 years of experience.
- Bench Scientist (Senior Associate Scientist): B.S./M.S. in biological sciences, biochemistry, or related fields. Recent graduate with 1 to 3 years of experience.
- LC-MS biological sample preparation involving multi-step processes to isolate, purify, and concentrate analytes.
- Operation of laboratory equipment.
- Demonstrated experience in successfully executing complex bioanalytical procedures.
- Proficient in aseptic technique.
- Proficient in benchtop bioreactor operation and associated analytical tools.
- Experience with bench scale cell culture and/or bacterial fermentation.
- In-depth knowledge of bioreactor operations: fed-batch, perfusion, and continuous modes of cell culture.
- Demonstrated ability to perform complex sample preparation workflows (preferably for biological mass spectrometry) with minimal supervision.
- Experience working in a laboratory environment.
- Expertise in immunoanalytical workflows, protein biochemistry, or proteomics techniques.
- Prior experience developing and maintaining scale-down models of commercial biopharmaceutical processes.
- Prior experience in developing commercially relevant cell culture processes to produce pharmacologically active proteins.
- Experience with control and data acquisition systems.
- Demonstrated experience developing or introducing new technology into commercial processes.
- Knowledge of all aspects of cell culture/fermentation, including batch, fed-batch, perfusion, and harvest/clarification operations.
- Familiarity with DoE and other statistical tools.
- Experience with processing and interpreting large data sets.
- Familiarity with regulatory filings, cGMP requirements, and operational constraints.
skills: Biology, Chromatography
Equal Opportunity Employer: Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status.
At Randstad, we welcome people of all abilities and want to ensure that our hiring and interview process meets the needs of all applicants. If you require a reasonable accommodation to make your application or interview experience a great one, please contact HRsupport@randstadusa.com.
Pay offered to a successful candidate will be based on several factors including the candidate's education, work experience, work location, specific job duties, certifications, etc. In addition, Randstad offers a comprehensive benefits package, including: medical, prescription, dental, vision, AD&D, and life insurance offerings, short-term disability, and a 401K plan (all benefits are based on eligibility).
This posting is open for thirty (30) days.
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
