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location: Ridgefield, Connecticut
job type: Contract
salary: $51.00 - 52.82 per hour
work hours: 9 to 5
education: Masters
responsibilities:
- Apply skill in solid-state NMR (ssNMR) spectroscopy to acquire and interpret (1D and 2D 1 H, 19 F, 13 C, 15 N, etc.) data for molecular structure elucidation.
- Apply ssNMR to characterize pharmaceutical materials such as particles, powders, and suspensions and to guide robust drug substance and drug product development.
- Use NMR expertise to evaluate and characterize a broad range of materials, including crystalline and non-crystalline small molecule APIs, biologics, excipients, drug product intermediates, and drug products.
- Apply quantitative ssNMR methods to measure components of APIs and drug products.
- Use molecular modeling and predictive tools with technologies such as solution/solid state NMR and X-ray crystallography to enable 3D structural evaluation at the atomic and molecular level.
- Ensure back-up and retrieval of all ssNMR data.
- Plan and perform experiments with minimal supervision to provide investigative support of structural predictions.
- Remain current with relevant scientific literature and apply knowledge to the design, modification and implementation of new experiments.
- Write protocols, methods and technical reports; provide scientific interpretation of results with minimal guidance.
- Present at internal scientific meetings.
qualifications:
- Master's Degree in Organic Chemistry or equivalent with 1-3 yrs. experience in the application of ssNMR Spectroscopy to structurally characterize pharmaceutically relevant small molecules.
- Background in use of solution NMR for structure elucidation is highly desired.
- Experience with solid-state NMR sample preparation, data acquisition and interpretation of multinuclear NMR data is required.
- Experience with implementing and trouble-shooting ssNMR experiments.
- Experience changing Bruker ssNMR probes is required.
- Basic understanding of molecular structure, inter-atomic distances, hydrogen bonding, torsion angle strain, hydrophobic and hydrophilic interactions.
- Experience in the application and interpretation of ssNMR to study biological systems is a plus.
- Understands the conceptual basis behind modern computational methods such as qm-DFT, Monte Carlo methods, etc.
- Knowledgeable in the routine use of molecular modeling software (example: Gaussian, Schrodinger, Materials Studio suite, CCDC software )
- Familiar with use of HPC clusters, Linux environment and associated job submission programs.
- Experience collaborating with diverse teams and demonstrated ability to work independently and with minimal supervision.
- Experience with preparing and analyzing membrane protein samples is a plus.
- Excellent laboratory practices to ensure safety and sample integrity.
- Background in use of solution NMR for structure elucidation is desired.
skills: Chemistry, Nuclear Magnetic Resonance (NMR) Spectroscopy
Equal Opportunity Employer: Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status.
At Randstad, we welcome people of all abilities and want to ensure that our hiring and interview process meets the needs of all applicants. If you require a reasonable accommodation to make your application or interview experience a great one, please contact HRsupport@randstadusa.com.
Pay offered to a successful candidate will be based on several factors including the candidate's education, work experience, work location, specific job duties, certifications, etc. In addition, Randstad offers a comprehensive benefits package, including: medical, prescription, dental, vision, AD&D, and life insurance offerings, short-term disability, and a 401K plan (all benefits are based on eligibility).
This posting is open for thirty (30) days.